Early Imaging Biomarkers in NSCLC

Completed

Conditions studied: Thoracic Cancer

In brief

The purpose of this study is to investigate if cardiac MRI, blood biomarkers, and lung CT scans can detect early changes to the associated with radiation therapy in patients receiving radiation treatment for thoracic cancer.

Key facts

Study ID

NCT03121287

Run by

University of Michigan Rogel Cancer Center

People needed

23

Starts

2015-09-23

Expected to finish

2019-01-01

Last updated by the study team

2019-08-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients receiving once daily fractionated intrathoracic radiation therapy for:
• Stage IIA-IIIB non-small cell lung cancer
• Limited stage small cell lung cancer
• Stage I-III esophageal cancer (neoadjuvant or definitive)
• Patients must be 18 years of age or older
• Must not be claustrophobic
• Must have adequate kidney function

You may not qualify if…

• Patients with small cell lung cancer receiving twice daily (b.i.d.) radiation
• Patients with esophageal cancer receiving trastuzamab
• Pregnancy or lactation
• Claustrophobia
• Inability to lie flat for 60-90 minutes
• Renal dysfunction with eGFR <60 mL/min/1.73 m2
• Allergy to gadolinium containing contrast media
• Implanted devices, metallic hazards or other conditions presenting a contraindication to 3Tesla cardiac MRI

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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