ARDS Esophageal Balloon Pressure Changes With Positioning Study
Stopped early
Conditions studied: ARDS, Respiratory Failure
In brief
The use of esophageal balloon catheters, which use esophageal pressure as a surrogate measurement for transpleural pressure, shows promise in improving outcomes of patients with severe acute respiratory distress syndrome (ARDS) requiring mechanical ventilator. The investigators hope to measure changes in in transpleural pressures in patients undergoing treatment with mechanical ventilation while switching from the supine, upright (head of bed \>30 degrees), and prone positions. The goal will be to measure the changes in chest wall and lung compliance in mechanically ventilated patients with changes in position.
Key facts
- Study ID
- NCT03120793
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 2
- Starts
- 2017-05-11
- Expected to finish
- 2020-03-01
- Last updated by the study team
- 2021-01-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age at least 18 years old, need for mechanical ventilation, moderate or severe ARDS, and the ability to tolerate prone positioning.
- Exclusion Criteria will be patients who:
- are deemed too ill by their clinicians to be included in the study
- have esophageal or nasopharyngeal pathology (such as tumors, sinusitis, epistaxis, ulcerations, recent surgery or bleeding varices) preventing insertion of the esophageal balloon catheter
- diverticulitis
- bronchopulmonary fistula
- solid-organ transplantation
- history of difficult intubation or airway management
- or contraindications to prone positioning (per the UNC Medical Intensive Care Unit Pronation Therapy protocol, attached)
Where it is running
- University of North Carolina, Chapel Hill — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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