Microbiome-mediated Weight, Anxiety, and Stress Dysregulation in Anorexia Nervosa

Completed

Conditions studied: Anorexia Nervosa

In brief

The purpose of this research study is to analyze the microorganisms residing in the gut of patients with anorexia nervosa. Research has begun to link changes in the intestinal microbiota with diseases such as inflammatory bowel disease (IBS), asthma, and obesity, but although some studies have investigated the intestinal microbiota in overweight/obese individuals, very little is known about the intestinal microbiota in underweight individuals. The investigators aim to identify the enteric bacterial groups associated with adiposity, BMI, anxiety, and stress in patients with anorexia nervosa.

Key facts

Study ID

NCT03119272

Run by

University of North Carolina, Chapel Hill

People needed

255

Starts

2016-04-01

Expected to finish

2020-10-01

Last updated by the study team

2020-10-23

Who can join

Age: 15 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Anorexia nervosa patient receiving treatment

You may not qualify if…

• history of gastrointestinal tract surgery
• history of inflammatory bowel diseases (IBD)
• history of irritable bowel syndrome (IBS)
• history of celiac disease
• history of any other diagnosis that could explain chronic or recurring bowel symptoms
• treatment in the last two months with antibiotics, non-steroid anti-inflammatory agents, or steroids.
• eating disorders or other major psychiatric or medical issue (for healthy controls).

Where it is running

• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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