RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Vomiting in Infants and/or Children, Nausea, Hematopoietic System--Cancer, Oncology
In brief
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving hematopoietic stem cell transplant (HSCT) conditioning, experience CIV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with psychiatric illness, does not interact with chemotherapy and is inexpensive. We hypothesize that the addition of olanzapine to standard antiemetics will improve chemotherapy-induced vomiting (CIV) control in children receiving highly emetogenic chemotherapy
Key facts
- Study ID
- NCT03118986
- Run by
- The Hospital for Sick Children
- People needed
- 200
- Starts
- 2017-08-10
- Expected to finish
- 2026-04-01
- Last updated by the study team
- 2025-10-08
Who can join
Age: 3 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
Where it is running
- All India Institute of Medical Sciences — New Delhi, National Capital Territory of Delhi, India (enrolling)
- The Children's Mercy Hospital — Kansas City, Missouri, United States (enrolling)
- Hospital for Sick Children — Toronto, Ontario, Canada (enrolling)
- University of California — San Francisco, California, United States (enrolling)
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
- Cancer Care Manitoba — Winnipeg, Manitoba, Canada (enrolling)
- Columbia University/Morgan Stanley Children's Hospital — New York, New York, United States
- Centre Hospitalier Universitaire Sainte-Justine, — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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