Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant

Completed · Phase 3

Conditions studied: Surgery

In brief

The purpose of this study is to compare two different medications (neostigmine/glycopyrrolate and sugammadex) to see if one drug improves patient comfort regarding the return of muscle strength after surgery.

Key facts

Study ID

NCT03116997

Run by

Memorial Sloan Kettering Cancer Center

People needed

201

Starts

2017-04-07

Expected to finish

2022-03-03

Last updated by the study team

2025-05-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients age 18 years of age or greater who are capable of giving consent
• Undergoing surgical procedures of expected length 6 </= hours requiring NMB

You may not qualify if…

• Pregnancy
• History of documented anaphylaxis or contraindication to any of the study medications
• Active coronary disease with a positive cardiac stress test
• History of severe chronic obstructive pulmonary disease (COPD) defined as an FEV1 < 50% of predicted
• Serum Creatinine >/= 2.0 mg/dL
• Severe hepatic dysfunction accompanied by coagulopathy
• Definition:
• Known liver Disease AND
• INR > 1.5 (except for patients on anticoagulants) AND
• Platelet count <100,00/ul without other obvious cause
• Chronic sustained release opioid for > 2 weeks duration pre op (in the 30 days prior to surgery)
• Use of toremifene
• Significant cognitive impairment or documented psychologic impairment
• Myasthenia gravis or other neuromuscular disease
• Patients who are not eligible for standard anesthetic induction, eg, those needing rapid sequence induction or awake fiberoptic bronchial intubation.
• American Society of Anesthesiologists (ASA) Status > 3

Where it is running

• Memoral Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Commack — Commack, New York, United States
• Memoral Sloan Kettering Westchester — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.