Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?

Completed · Not applicable

Conditions studied: Osteoarthritis

In brief

The purpose of this study is to investigate antibiotic treatment to target bacteria about the shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder surgeries and is thought to contribute to periprosthetic joint infections, pain, and failure of total shoulder arthroplasty as well as other shoulder surgeries. This study is investigating adding an FDA approved antibiotic that is commonly used for treatment of this bacteria and many common infections. The investigators will take intraoperative cultures to look for the presence or absence of specific bacteria. The investigators are conducting this trial to see if adding another antibiotic to specifically target this common bacteria found around the shoulder will be effective.

Key facts

Study ID

NCT03115177

Run by

Rush University Medical Center

People needed

56

Starts

2015-11-01

Expected to finish

2017-02-01

Last updated by the study team

2018-06-15

Who can join

Age: 40 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing primary total shoulder arthroplasty at Rush University Medical Center

You may not qualify if…

• Patients with prior shoulder surgery of any kind
• Patients with a known infection or history of infection with clinical signs such as elevated erythrocyte sedimentation rate, C-reactive protein, positive culture aspiration
• Patients with a known allergy to doxycycline
• Patients with a known allergy to cefazolin or penicillin

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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