Safety and Activity of Digoxin With Decitabine in Adult AML and MDS

Stopped early · Phase 1/Phase 2

Conditions studied: Acute Myeloid Leukemia, Myelodysplastic Syndromes

In brief

The primary hypothesis is that digoxin can be safely added to decitabine and will increase the response rates in medically unfit patients with newly diagnosed AML/MDS or those with relapsed/refractory AML/MDS. Furthermore, it is hypothesized that the addition of digoxin to decitabine will result in distinct epigenetic alterations in AML/MDS patients.

Key facts

Study ID: NCT03113071
Run by: Fox Chase Cancer Center
People needed: 1
Starts: 2017-06-02
Expected to finish: 2019-03-11
Last updated by the study team: 2021-03-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients must have a confirmed diagnosis of one of the following:
Newly diagnosed AML (excluding APL)
Newly diagnosed intermediate-2 (INT-2) or high-risk MDS
Relapsed or Refractory AML, or INT-2 or high-risk MDS
For patients with refractory disease they must be at least 4 weeks out from most recent therapeutic intervention.
Age > 18 years.
ECOG performance status 0 - 2.
Patients must have normal organ function as defined below:
Total bilirubin within normal institutional limits
AST/ALT (SGOT/SGPT) < 2 times institutional normal limits
Creatinine within normal institutional limits OR
Creatinine clearance > 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal
Ability to understand and willingness to sign a written informed consent and HIPAA consent document.
Agreement on the part of any male participant to use effective contraception during sexual activity throughout the duration of treatment and for 2 months after discontinuation, for protection against the risk of embryofetal toxicity.

You may not qualify if…

Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study or those who have not recovered from adverse events (less than or equal to Grade 1 toxicity) due to agents administered more than 4 weeks earlier.
Patients receiving any other investigational agents.
Patients with known brain metastases, active infection, or untreated CNS leukemia.
Patients with prior or current history of digoxin exposure.
Patients requiring treatment with one or more medications known to interact adversely with digoxin, namely thiazide and/or loop diuretics, quinidine, ritonavir, amiodarone, cyclosporine, itraconazole, propafenone, spironolactone, verapamil.
Patients requiring treatment with one or more beta-blockers (metoprolol, atenolol, propranolol) or calcium channel blockers with AV-nodal blocking activity (verapamil, diltiazem).
Patient with history of prior exposure to decitabine.
Patients eligible for intensive induction chemotherapy and "Medically unfit" based on a TRM score ≥ 13.1*
TRM Score= A scoring model which predicts early death following intensive induction chemotherapy in newly diagnosed AML.
Model looks at ECOG PS, Age, Platelet Count, Albumin, 2nd AML, WBC, % Peripheral Blasts, Creatinine
Score above 13.1 associated with 31%+ chance of death after induction
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Known HIV-positive patients on combination anti-retroviral therapy are ineligible because of the potential for pharmacokinetic interactions with digoxin. In addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy.
Pregnant or breast feeding

Where it is running

Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
Jeans Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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