Out-of-hospital Cardiac Arrest (OHCA) Biomarkers
Completed
Conditions studied: Neurological Outcome, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Brain Anoxia Ischemia, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Cardiac Arrest With Successful Resuscitation, Cardiac Arrest, Out-Of-Hospital, Brain Injuries
In brief
Few early prognostic indicators are currently available for patients' families and clinicians following out of hospital cardiac arrest (OHCA), and blood biomarkers may be of prognostic value in these cases. Brain tissue is highly dependent upon aerobic respiration, and oxygen deprivation result in irreversible neuronal cell injury. Peptides released into the blood by injured neuronal cells can be measured to estimate degree of injury, and potentially predict long term neurological outcome.
Key facts
- Study ID
- NCT03112486
- Run by
- University of Florida
- People needed
- 32
- Starts
- 2017-05-26
- Expected to finish
- 2020-01-28
- Last updated by the study team
- 2020-05-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- >18 years old
- Study cohort:
- Non-traumatic out of hospital cardiac arrest
- Control cohort:
- Chest pain of non-cardiac etiology
You may not qualify if…
- Both cohorts:
- Females of child bearing age with positive pregnancy test
- Neurodegenerative disease or other neurological disorder (dementia, Parkinson's disease, multiple sclerosis, seizure disorder, or brain tumours)
- History of neurosurgery within the last 30 days Acute brain injury within the last 30 days (ischemic/ haemorrhagic stroke, traumatic brain injury) Subject is anemic OR donated blood within the last 8 weeks OR has a hematological disorder that requires transfusions Subject has history of liver failure OR renal failure
- Study cohort:
- Advanced directives against resuscitation Traumatic cardiac arrest In hospital cardiac arrest Failure to attain ROSC + visible signs of death (livor mortis, rigor mortis)
- Control cohort:
- EKG changes: New ST-elevation consistent with myocardial infarction NSTEMI Hemodynamically unstable
Where it is running
- Univeristy of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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