Incidence of Postoperative Neuromuscular Blockade in Post-Anesthesia Care Unit at Parkland Hospital: Does Size Matter?
Completed
Conditions studied: Residual Neuromuscular Blockade
In brief
This prospective, observational study will assess 100 subjects in the post-anesthesia care unit (PACU) at Parkland Hospital. Upon arrival to the PACU, patients' train-of-four (TOF) ratio will be calculated using the StimPod NMS450 accelerometer to determine the presence of any residual paralysis. Any patient with a TOF ratio \< 0.9 will be reassessed every 10 minutes until the ratio is ≥0.90. The time it takes to reach a TOF ratio ≥0.9 will be recorded. Subjects will be classified according to BMI categories: lean as \<30 kg/m2, obese as 30≤BMI≤39.9 kg/m2, and morbidly obese as BMI ≥40 kg/m2. This data will serve as a baseline to assess the incidence of residual NMB that currently occurs in our PACU so that we may use this pilot data to design future studies that aim to reduce the incidence of residual NMB.
Key facts
- Study ID
- NCT03111082
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 100
- Starts
- 2017-07-11
- Expected to finish
- 2018-04-16
- Last updated by the study team
- 2018-04-25
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-80 years old
- Undergoing non-emergent surgery with general endotracheal anesthesia
- ASA physical status classification 1 to 4
- Willing and able to consent in English or Spanish
- No personal history of neuromuscular disease
You may not qualify if…
- Age less than 18 or older than 80
- Patient does not speak English or Spanish
- Planned postoperative intubation or ICU admission
- Allergy to sugammadex, neostigmine, glycopyrrolate, or rocuronium
- Family or personal history of malignant hyperthermia
- Patient refusal
- Monitored anesthesia care (MAC) or regional anesthesia planned
- Pregnant or nursing women
- "Stat" (emergent) cases
- Estimated creatinine clearance <30 mL/min
- Pre-existing muscle weakness of any etiology
Where it is running
- Parkland Health & Hospital System — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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