Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD

Completed

Conditions studied: Chronic Obstructive Pulmonary Disease, Diastolic Dysfunction

In brief

This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD. To assess changes within subjects from stable to acute phase, a number of comparisons will be made in subjects enrolled during acute exacerbation with similar measurements made in the stable phase after recovery from exacerbation after at least 35 days from index hospitalization or prior exacerbation.

Key facts

Study ID

NCT03110614

Run by

University of Alabama at Birmingham

People needed

94

Starts

2013-11-25

Expected to finish

2021-08-30

Last updated by the study team

2021-10-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients age 18 and older
• Patients admitted to the general medicine or pulmonary floors, or the medical intensive care unit with a primary diagnosis of acute exacerbation of COPD will be eligible for the study.

You may not qualify if…

• Patients with a secondary diagnosis of congestive heart failure and other respiratory conditions that the investigator's deem could confound the diagnosis including but not limited to pneumonia, bronchiectasis and lung cancer will be excluded.
• Pregnant or breastfeeding women will be excluded.
• Patients with conditions that preclude an adequate echocardiogram such as hemodynamically significant arrhythmias will also be excluded.

Where it is running

• UAB Lung Health Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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