Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea

Stopped early · Phase 2/Phase 3

Conditions studied: Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications

In brief

The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.

Key facts

Study ID: NCT03109418
Run by: University of Alabama at Birmingham
People needed: 9
Starts: 2016-06-02
Expected to finish: 2018-09-12
Last updated by the study team: 2019-12-19

Who can join

Age: 19 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

aged 19-100
scheduled to undergo general ENT or Orthopedic Surgery
diagnosis of obstructive sleep apnea as confirmed by sleep study or deemed high risked for obstructive sleep apnea by clinical predictors (greater than 4 clinical predictors of obstructive sleep apnea as described by STOP BANG ).

You may not qualify if…

positive pregnancy test
ASA > III
history of alcohol or narcotic abuse in last 90 days
significant cardiovascular or respiratory disease (baseline oxygen saturation below 92%)
significant psychiatric or neurologic disease
history of significant hepatic or renal disease (baseline creatinine>1.5)
history of allergy or contraindication to anesthetic agents or ketamine including patients with increased ICP
increased IOP
severe arrhythmias
history of delirium
history of hallucinations
history of psychosis
history of uncontrolled seizures
potential risk for malignant hyperthermia (family history)
history of difficult intubation that would preclude standard induction of anesthesia
prisoners
persons who are mentally impaired
non-English speakers

Where it is running

UAB Department of Anesthesiology and Perioperative Medicine — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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