Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia

Completed · Phase 4

Conditions studied: Amblyopia

In brief

The research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits. Recent work suggests that there is limited neural plasticity in the visual system of adults with amblyopia. This study is aimed at understanding and increasing this plasticity. In this study, the investigators aim to understand how the amblyopic brain learns and how this process is affected by a drug called donepezil, which is sometimes given as a treatment for Alzheimer's disease. The investigators hope that this study will help to identify the chemical components that help the brain to learn, as well as the mechanism of amblyopia. The investigators also plan to test the normal periphery, as control.

Key facts

Study ID

NCT03109314

Run by

Dennis Levi

People needed

20

Starts

2012-05-01

Expected to finish

2018-12-01

Last updated by the study team

2019-01-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• corrected visual acuity being 20/30 or worse in the poorer eye (at least 20/20 in the better eye)
• reduced stereoacuity
• normal retina

You may not qualify if…

• with other diagnosed eye diseases
• Subjects with normal vision
• Inclusion Criteria:
• corrected visual acuity at least 20/20 in each eye
• normal stereoacuity
• normal retina
• Exclusion Criteria:
• with other diagnosed eye diseases

Where it is running

• University of California, Berkeley — Berkeley, California, United States

Full record on ClinicalTrials.gov

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