Metabolomics for Biomarker Discovery in Children With EoE
Completed
Conditions studied: Eosinophilic Esophagitis
In brief
The investigators are seeking to enroll 8 children ages 2-18 already undergoing upper endoscopy. For the purposes of research, a peripheral blood and clean catch urine specimen will be obtained to measure plasma and urine metabolomics. The data will be used to determine if there are any key differences in the metabolite profile of subjects found to have eosinophilic esophagitis (EoE) versus non-EoE subjects. Once these metabolites are identified, the investigators will seek to enroll many more subjects for a validation phase.
Key facts
- Study ID
- NCT03107819
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 24
- Starts
- 2017-03-29
- Expected to finish
- 2018-03-31
- Last updated by the study team
- 2018-05-01
Who can join
Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pediatric patients, ages 2-18 years, undergoing EGD with biopsies of the esophagus.
- Children with known EoE will only be enrolled if his/her biopsy on the day of specimen collection demonstrates ≥15 eosinophils (eos) per high power field (hpf).
You may not qualify if…
- Presence of other disorders associated with similar clinical, histological or endoscopic features, such as proton pump inhibitor (PPI)-responsive esophageal eosinophilia, esophageal eosinophilia associated with gastroesophageal reflux, Crohn's disease, infectious esophagitis (i.e. herpes simplex virus or candida), drug-associated esophagitis, collagen vascular disease, hypereosinophilic syndrome and eosinophilic gastroenteritis.
- Children with known EoE and biopsy demonstrating <15 eos/hpf at the time of specimen collection.
- Inability to provide a clean catch urine specimen (i.e. not toilet-trained).
Where it is running
- University of Texas Health Science Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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