Delivering a Diuretic Into the Liver Artery Followed by Plugging up the Artery to Starve Out Liver Cancer Cells

Running, not enrolling · Phase 1/Phase 2

Conditions studied: Unresectable Hepatocellular Carcinoma

In brief

The purpose of this study is to test the safety of Bumetanide , at different doses to find out what effects, if any, it has on people who undergo tumor TAE as part of their regular care. Bumetanide is a commonly used medication to reduce the amount of water in the body.

Key facts

Study ID

NCT03107416

Run by

Memorial Sloan Kettering Cancer Center

People needed

30

Starts

2017-04-05

Expected to finish

2027-04-05

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with diagnoses of HCC according to European Association for the Study of Liver disease (EASL) criteria for diagnosis (See Appendix 1). Regional lymphadenopathy will be allowed.
• Any virus status accepted (e.g. Hepatitis C etc.)
• Any prior liver treatment
• Patients within unresectable HCC
• At least 18 years old
• ECOG performance status 0 or 1
• Radiographically measurable disease per mRECIST 1.1
• Meets standard of care to undergo embolization

You may not qualify if…

• Women who are pregnant or lactating
• Documented hypersensitivity to bumetanide or sulfonamides
• Patients with resectable HCC
• High risk for post-embolization hepatic failure:
• °Child's C cirrhosis
• °> 80% liver involvement by tumor
• Contraindication to angiography/embolization including:
• Patients cannot receive contrast:
• Severe allergic reaction to contrast despite premedication
• Poor renal function not on dialysis
• Other, based on judgment of the investigator
• ECOG score 2
• Main portal vein tumor thrombus
• BCLC D = patients with distant metastasis

Where it is running

• Memorial Sloan Kettering Basking Ridge (Consent and follow-up only) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (Consent and follow-up only) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Consent and follow-up only) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Westchester (Consent and follow-up only) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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