Use of NAC in Prevention of Hangover Symptoms; Independent Alcohol Consumption Protocol

Stopped early · Not applicable · Has a placebo group

Conditions studied: Prevention of Hangover Using N-Acety Cysteine

In brief

This is a double-blinded study involving healthy non-alcoholic (self-reported) volunteers over the age of 21. Consent is obtained prior to participation in the study while the participant is sober. Volunteers are recruited from residency programs, hospital employees, emergency medical personnel, and friends of the study investigators. If the volunteers choose to drink, they can participate in the study the night of ingestion of alcohol. There is no amount we ask them to drink, and we allow them to withdraw from the study at any time. We never force them to drink alcohol, or even encourage it. The participation is completely voluntary, if they would like to participate and if they choose to drink alcohol, we ask them to participate in the placebo controlled study in the safety of their own home. Then materials for the study are given out prior to their participation. An envelope is given with the questionnaire, and a small packet containing 3 pills of either NAC or placebo, and a small smear of Vicks vapor rub concealed in a small packet. At the end of their alcohol ingestion, the volunteer is asked to estimate the number roof drinks consumed and take 1 capsule per 3 drinks consumed of either 600 mg N-Acetyl-L-Cysteine or placebo capsules. In the morning, each participant fills out a Hangover Symptom Score questionnaire . A random number generator is used to determine placebo or NAC first, then the participant is given the other treatment at their subsequent encounter. Then study is being conducted over a series of many months, and data can be analyzed by the hangover symptoms scale data when using NAC compared to placebo. The data will be analyzed using the numerical values of each category for hangover classification and compare the placebo data to the control data.

Key facts

Study ID

NCT03104959

Run by

St. Luke's Hospital and Health Network, Pennsylvania

People needed

200

Starts

2016-01-01

Expected to finish

2018-06-06

Last updated by the study team

2018-06-11

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age over 21 years
• able and agrees to drink alcohol

You may not qualify if…

• alcoholism (self-reported)
• pregnancy
• reactive airway disease
• diabetes
• kidney/bladder stones
• kidney disease
• liver disease
• stomach ulcer
• organ transplant patients
• dialysis patients
• allergies to alcohol, eggs, milk, or wheat
• volunteers taking the following medications: opiate pain medication, activated charcoal, ampicillin,carbamazepine, cephalosporidine, methicillin, nitroglycerine, oxacillin, penicillin G, quinicillin

Where it is running

• St. Luke's Hospital — Bethlehem, Pennsylvania, United States

Full record on ClinicalTrials.gov

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