Switching to Low Oxidant Content Cigarettes in Adult Smokers
Completed · Not applicable
Conditions studied: Nicotine, Oxidative Stress
In brief
The overall objective of this clinical study is to determine if smokers who switch from their usual high reactive oxygen and nitrous oxide species (ROS/NOS) products to a low ROS/NOS product exhibit increased or decreased levels of oxidative stress/damage, respectively.
Key facts
- Study ID
- NCT03102931
- Run by
- Milton S. Hershey Medical Center
- People needed
- 30
- Starts
- 2017-07-11
- Expected to finish
- 2018-03-06
- Last updated by the study team
- 2019-03-04
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 21-65
- Smoke 10 cigarettes per day or more for at least one year
- Read and write in English
- Menthol and nonmenthol smokers
- Able to understand and provide consent to study procedures
- Plan to live in the local area for the next 3 months
- Women not pregnant or nursing and taking steps to avoid pregnancy
- No quit attempt in the last one months and not planning to quit in the next 3 months (ensuring stability of smoking)
You may not qualify if…
- Currently pregnant or nursing
- Unstable or significant medical conditions that affect oxidative stress, such as COPD, kidney failure, heart disease, stroke, cancer, tumors, lung or respiratory disease, diabetes, liver disease, autoimmune disorder, rheumatoid arthritis, infectious disease or fibromyalgia.
- Use of non-cigarette nicotine delivery
- History of difficulties providing blood samples: fainting, poor veins, anxiety, etc.
- Current or recent history of substance or alcohol abuse
- No more than seven alcoholic drinks a week, and/ or >two drinks a day
- Use of a high dose antioxidant supplement prior to 1 month
- Currently smoking cigarettes that will be used for the study (Pall Mall Red or American Spirit Dark Green)
Where it is running
- Penn State Hershey — Hershey, Pennsylvania, United States
Full record on ClinicalTrials.gov
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