Allograft Dysfunction in Heart Transplant

Recruiting now · Phase 4

Conditions studied: Heart Transplant Failure and Rejection

In brief

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

Key facts

Study ID

NCT03102125

Run by

Paul Kim

People needed

376

Starts

2019-10-01

Expected to finish

2027-01-02

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 18 years old.
• At least three months status post heart transplantation.

You may not qualify if…

• Biopsy proven acute rejection episode in the past 3 months.
• Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.
• Uncontrolled obstructive ventilatory disease including asthma and COPD.
• History of generalized tonic-clonic seizures.
• Second or third degree AV nodal block.
• Sinus node dysfunction.
• Contraindications to MRI including cardiovascular implantable electronic devices.
• Renal dysfunction with an estimated GFR less than 30 mL/min/1.73m2.
• Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.
• Systolic blood pressure greater than 180 or less than 85 mmHg.
• Diastolic blood pressure greater than 120 or less than 40 mmHg.
• Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.

Where it is running

• UC San Diego — La Jolla, California, United States (enrolling)

Full record on ClinicalTrials.gov

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