A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Preserved Ejection Fraction
Completed · Phase 2 · Has a placebo group
Conditions studied: Heart Failure
In brief
The objective of the study is to find the optimal dose of once daily oral neladenoson bialanate (BAY1067197) when given in addition to appropriate therapy for specific comorbidities.
Key facts
- Study ID
- NCT03098979
- Run by
- Bayer
- People needed
- 305
- Starts
- 2017-05-10
- Expected to finish
- 2018-06-20
- Last updated by the study team
- 2019-07-23
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men or women aged 45 years and older
- Diagnosis of chronic heart failure, NYHA (New York Heart Association) class II-IV, LVEF (left ventricular ejection fraction) ≥ 45% and elevated NT-proBNP
You may not qualify if…
- Acute decompensated heart failure within the past 4 weeks
- Inability to exercise
- Previous diagnosis of HFrEF (heart failure with reduced ejection fraction) (LVEF < 40%)
Where it is running
- St. Louis Heart & Vascular, PC — St Louis, Missouri, United States
- BryanLGH Medical Center East — Lincoln, Nebraska, United States
- Wake Forest Baptist Health — Winston-Salem, North Carolina, United States
- Universitätsklinikum St. Pölten — Sankt Pölten, Lower Austria, Austria
- Medizinische Universität Graz — Graz, Styria, Austria
- Krankenhaus St. Josef Braunau — Braunau am Inn, Upper Austria, Austria
- Krankenhaus der Elisabethinen Linz GmbH — Linz, Upper Austria, Austria
- Allgemeines Krankenhaus der Stadt Wien — Vienna, Austria
- Krankenhaus Hietzing — Vienna, Austria
- Jessa Ziekenhuis — Hasselt, Belgium
- CHR de la Citadelle — Liège, Belgium
- AZ Delta — Roeselare, Belgium
- Spec Hosp for Active Treatm in Cardiology Sv Georgi Pernik — Pernik, Bulgaria
- Specialized Hospital for Actrive Treatm of Card - Pleven — Pleven, Bulgaria
- Medical Center Cardiohelp — Sofia, Bulgaria
- NMTH Tzar Boris III — Sofia, Bulgaria
- UMHAT Tsaritsa Joanna-ISUL EAD Sofia — Sofia, Bulgaria
- MCOMH Preventsia-2000 — Stara Zagora, Bulgaria
- St. Vincenz und Elisabeth Hospital, Kathol. Klinikum Mainz — Mainz, Rhineland-Palatinate, Germany
- Klinische Forschung Dresden GmbH — Dresden, Saxony, Germany
- HELIOS Klinikum Erfurt GmbH — Erfurt, Thuringia, Germany
- Charité Campus Virchow-Klinikum (CVK) — Berlin, Germany
- KAT General Hospital of Athens — Kifisia / Athens, Attica, Greece
- G. Gennimatas General State Hospital of Athens — Athens, Greece
- Northwestern University — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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