Suprachoroidal Injection of CLS-TA in Patients With Non-infectious Uveitis

Completed · Phase 3

Conditions studied: Uveitis, Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate, Panuveitis

In brief

This open-label study is designed to evaluate the safety of suprachoroidally administered triamcinolone acetone injectable suspension, CLS-TA, in patients with non-infectious uveitis with and without macular edema.

Key facts

Study ID

NCT03097315

Run by

Clearside Biomedical, Inc.

People needed

38

Starts

2017-04-04

Expected to finish

2018-01-24

Last updated by the study team

2021-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of active or inactive non-infectious uveitis (pan, anterior, intermediate and posterior)
• ETDRS BCVA score of ≥ 5 letters read in the study eye

You may not qualify if…

• Any active ocular disease or infection in the study eye other than uveitis
• Intraocular pressure > 22 mmHg or uncontrolled glaucoma in the study eye; patients with IOP of 22 or less in the study eye not excluded with no more than 2 IOP-lowering medications.
• Any uncontrolled systemic disease that, in the opinion of the Investigator, would preclude participation in the study
• Any topical ocular corticosteroid in the 10 days prior to baseline; intraocular or periocular corticosteroid injections in the 2 months prior to baseline; an OZURDEX implant in the 6 months prior to baseline; RETISERT or ILUVIEN implant in the 3 years prior to baseline.

Where it is running

• Retinal Consultants of Arizona — Phoenix, Arizona, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View, California, United States
• Retina Group of Florida — Fort Lauderdale, Florida, United States
• Marietta Eye Clinic — Marietta, Georgia, United States
• Midwest Eye Retina Practicing at Midwest Eye Institute — Indianapolis, Indiana, United States
• Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
• Texas Retina Associates — Dallas, Texas, United States
• Retina Consultants of Houston — Houston, Texas, United States
• Virginia Eye Consultants — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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