Amnion-Chorion Allograft Barrier Used for Root Surface and Guided Tissue Regeneration
Completed · Not applicable
Conditions studied: Periodontal Diseases
In brief
The purpose of this pilot project is to evaluate the efficacy of application of Amnion-Chorion allograft membrane on the root surface of periodontally diseased teeth in conjunction with bone substitute covered by Amnion-Chorion allograft in a combination Guided Tissue Regeneration (GTR) treatment of periodontal intrabony and furcation defects.
Key facts
- Study ID
- NCT03095976
- Run by
- Indiana University
- People needed
- 4
- Starts
- 2017-06-14
- Expected to finish
- 2019-09-10
- Last updated by the study team
- 2021-04-14
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- ASA class I or II;
- age >18 years old;
- Non-smoker;
- diagnosis of chronic or aggressive periodontitis previously treated with nonsurgical mechanical debridement; 5) patients have at least one two-wall intrabony defect in interproximal areas with radiographic evidence of an intrabony component of ≥ 4 mm, PPD ≥ 6 mm with 1-wall or 2-wall or combination of those defects;
- Glickman Grade II furcation involvement on buccal of mandibular or maxillary first or second molars without soft tissue exposure of furcation entrance; 7) tooth mobility Miller Grade <1; 8) more than 2mm of keratinized tissue with those selected teeth.
You may not qualify if…
- did not meet all inclusion criteria;
- pregnancy or nursing woman;
- subjects with active systemic or localized infection (exclude chronic periodontitis);
- poor compliance or failure to maintain good oral hygiene as ascertained by the presence of full-mouth plaque score ≥ 20%;
- restorations or caries on root surfaces or untreated endodontic infections;
- participants received periodontal surgical treatment on the same site of this study within 2 years;
- use of systemic or local antibiotics on the anticipated surgical sites during the past 3 months.
Where it is running
- Indiana University School of Dentistry — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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