Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB

Running, not enrolling · Not applicable

Conditions studied: Obesity

In brief

The purpose of this study is to compare the metabolic responses to low-carbohydrate and standard-carbohydrate meals in African Americans and non-Hispanic White adults with obesity and the effect of weight loss induced by low-calorie diet (LCD) or Roux-en-Y gastric bypass (RYGB) on the metabolic responses to low-carbohydrate and standard meals. Participants will consume: 1) a standard-carbohydrate meal (\~49 g glucose) and 2) a low-carbohydrate (\~3.4 g glucose) meal on separate study visits performed in a randomized order. We will evaluate the meals' effect before and after \~16-18% weight loss on postprandial i) insulin kinetics, ii) glucose kinetics iii) β-cell function; iv) plasma triglyceride and non-esterified fatty acid concentrations; v) plasma hormone concentrations; vi) plasma cytokine concentrations; vi) plasma metabolomics; and vii) adipose tissue transcriptomics.

Key facts

Study ID

NCT03091725

Run by

Washington University School of Medicine

People needed

30

Starts

2017-04-25

Expected to finish

2026-12-01

Last updated by the study team

2026-03-17

Who can join

Age: 25 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Surgery Group (RYGB):
• Males and Females
• Scheduled for RYGB surgery
• Body Mass Index 35-60 kg/m²
• Without Type 2 Diabetes (T2D)
• LCD group:
• Males and Females
• Body Mass Index 35-60 kg/m²
• Without Type 2 Diabetes (T2D)

You may not qualify if…

• Regular use of tobacco products
• Previous intestinal resection
• Pregnant or breastfeeding
• Evidence of significant organ system dysfunction or disease other than obesity and T2D
• Use of any medication that might, in the opinion of the investigator, affect metabolic function
• Exercise ≥90 minutes per week
• Use or past use of hormone replacement therapy within the past 6 months

Where it is running

• Beth Henk — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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