The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis

Withdrawn before enrolling · Not applicable

Conditions studied: Sepsis, Thrombocytopenia

In brief

Sepsis is life-threatening and dysregulated response to infection that results in endothelial activation and dysfunction that leads to systemic microvascular leak and multiple-organ failure. This study will identify patients that have sepsis with thrombocytopenia and randomize them to receive a unit of platelets or an equivalent volume of saline.

Key facts

Study ID

NCT03090919

Run by

Susan Smyth

People needed

0

Starts

2017-01-03

Expected to finish

2021-05-31

Last updated by the study team

2021-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of informed consent prior to any study specific procedures
• Female and/or male, age >18 years
• Diagnosis of sepsis based on the Third International Consensus Definitions for Sepsis and Septic Shock
• Platelet count ≤ 50,000/μL

You may not qualify if…

• Active major bleeding requiring blood transfusion
• Other causes of thrombocytopenia such as idiopathic thrombocytopenic purpura, high clinical suspicion for heparin-induced thrombocytopenia (or other form of consumptive coagulopathy).

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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