Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure

Completed · Not applicable

Conditions studied: Smokers, Never Smokers

In brief

This study intends to evaluate the nasal mucociliary clearance (NMC) by determining the value obtained for saccharin transit time (STT) test over the course of 12 hours following a single cigarette use in adult smokers, to compare it relative to never smokers, and to examine the relationship between plasma nicotine levels and STT value in smokers and never smokers. Safety will also be monitored during the study. The planned maximum study duration for a single study participant from Screening through completion of study will be 33 days.

Key facts

Study ID

NCT03086707

Run by

Philip Morris Products S.A.

People needed

14

Starts

2017-01-21

Expected to finish

2017-09-29

Last updated by the study team

2020-11-20

Who can join

Age: 25 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may not qualify if…

• As per the Investigator's judgment, the subject cannot participate in the study for any reason (e.g., medical, psychiatric, and/or social reason).
• Inability to taste sweet within 60 minutes in the STT test.
• Any condition the Principal Investigator or designee has cause to believe would interfere with the procedures for upper or lower airway function. This could include, but is not limited to, nasal/septum deviations, or nasal polyps or nasal allergies.

Where it is running

• Inflamax Research - Neptune — Neptune City, New Jersey, United States
• Inflamax Research - Newark — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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