Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke

Completed · Not applicable · Has a placebo group

Conditions studied: Stroke, Stroke, Chronic, Stroke, Middle Cerebral Artery With Infarction

In brief

This study uses a form on non-invasive brain stimulation called transcranial magnetic stimulation to understand 1) understand how the brain learns post-stroke and 2) assess non-invasive brain stimulation as an addition to current stroke rehabilitation approaches. In two study arms the investigators will compare the effect of active transcranial magnetic stimulation paired with motor practice with placebo (or sham) transcranial magnetic stimulation paired with the same motor practice.

Key facts

Study ID

NCT03086551

Run by

University of Michigan

People needed

12

Starts

2016-04-01

Expected to finish

2019-03-30

Last updated by the study team

2020-04-27

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 50-75 years
• movement-related deficit associated with first time middle cerebral artery stroke
• greater than 6-months post-stroke
• Fugl-Meyer score between 15 and 60
• ability to elicit a motor evoked potential from the ipsilesional cortex

You may not qualify if…

• a score <27 on the Mini-Mental Status Exam
• a score of <123 on the Mattis Dementia Rating Scale
• a score of <13 on the Frenchay Aphasia Screen
• a history of seizure/epilepsy, head trauma, major psychiatric diagnosis, neurodegenerative disorder or substance abuse
• a history of congestive heart failure
• systolic blood pressure above 120 mmHg and/or diastolic pressure above 80 mmHg
• the taking of any GABAergic, NMDA-receptor antagonist or other drug known to influence the neural receptors that facilitate neural plasticity
• an infarct resulting from ischemic stroke of anterior or posterior cerebral artery OR an infarct that encroaches within 2cm of the site of cTBS stimulation
• absence of an MEP in response to single pulse transcranial magnetic stimulation over ipsilesional M1 and 10) any other contraindication to TMS or MRI.

Where it is running

• Human Sensorimotor Laboratory, School of Kinesiology, University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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