Patient-Driven Transfusion Thresholds in Hematological Disorders: A Pilot Study
Withdrawn before enrolling · Not applicable
Conditions studied: Anemia, Aplastic Anemia, Bone Marrow Failure, Hematopoietic and Lymphoid Cell Neoplasm, Leukemia, Myelodysplastic Syndrome
In brief
This pilot study evaluates safety of administration of red blood cell transfusions requested by patients based on their symptoms instead of levels of hemoglobin for the treatment of chronic anemia in patients with blood disorders.
Key facts
- Study ID
- NCT03086252
- Run by
- Emory University
- People needed
- 0
- Starts
- 2017-07-24
- Expected to finish
- 2018-05-31
- Last updated by the study team
- 2018-07-26
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed with hematological malignancy or marrow failure syndrome such as but not limited to: aplastic anemia, myelodysplastic syndrome or leukemia
- Chronic transfusion-dependent anemia with exposure to at least 5 RBCT
- Interested in reducing transfusion exposure
- Willing to sign informed consent
You may not qualify if…
- Recent acute bleeding requiring intervention in less than 24 hours
- Hemoglobin levels < 6 g/dL
- Acute leukemia receiving induction chemotherapy
- Any patient with known ischemic heart disease, history of congestive heart failure, history of stroke, or cardiac arrhythmia for which the patient requires medication or a medical device
- Oxygen dependent
- Oxygen saturation below 92% on room air
- Receiving erythropoietin stimulating agent
- Thalassemia major or sickle cell disease requiring blood transfusion
- Undergoing major surgery
- Hemolytic anemia
- Coagulopathies including disseminated intravascular coagulation (DIC), receiving anticoagulant or antiplatelet agents
- Diagnosed with chronic obstructive pulmonary disease (COPD) oxygen dependent
- Pregnancy
- Participation in a therapeutic clinical trial
Where it is running
- Emory University/Winship Cancer Institute — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.