A Dye for the Detection of Cancer of the Tongue and Mouth

Running, not enrolling · Phase 1/Phase 2

Conditions studied: Oral Squamous Cell Carcinoma (OSCC)

In brief

The purpose of this study is to test if an investigational dye, called PARPi-FL, can be used to detect this type of cancer. This will be the first time that PARPi-FL is being tried in people. First, the investigators will test the safety of PARPi-FL at different doses to find out what effects, if any, it has on people. The investigators will also see which amount of PARPi-FL is best suited to detect cancers of the mouth and tongue.

Key facts

Study ID

NCT03085147

Run by

Memorial Sloan Kettering Cancer Center

People needed

23

Starts

2017-03-15

Expected to finish

2027-07-01

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is ≥ 18 years old
• Histologically or cytologically proven squamous cell carcinoma of the oral cavity or pharynx (OSCC)
• Scheduled to undergo surgery at MSK
• Any tumor stage, any N, M0
• ECOG performance status 0 or 1

You may not qualify if…

• Any surgical therapy in the area of the oral cavity or pharynx within the last 2 weeks
• Prior or ongoing treatment with a PARP1 inhibitor
• Known hypersensitivity to Olaparib
• Known hypersensitivity to PEG Eligibility criteria will be assessed by an experienced oral surgeon, typically the Co-PI of the study.

Where it is running

• Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (Consent only) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Consent only) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Suffolk-Commack (Consent only) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Memorial Sloan Kettering Nassau (Consent only) — Rockville Centre, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.