Impact of Narrowband UVB Phototherapy on Systemic Inflammation in Patients With Atopic Dermatitis

Completed · Not applicable

Conditions studied: Atopic Dermatitis

In brief

Atopic dermatitis (eczema) is a chronic inflammatory disease that causes significant morbidity and is now known to be associated with cardiovascular disease. Research such as this will add to the understanding of the skin as a contributor to systemic inflammation, and it is important to clarify whether skin-only treatment can alleviate systemic inflammation, and potentially influence cardiovascular risk factors.

Key facts

Study ID

NCT03083730

Run by

Rockefeller University

People needed

6

Starts

2017-07-19

Expected to finish

2020-02-24

Last updated by the study team

2020-02-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ATOPIC DERMATITIS COHORT
• At least 18 years of age
• >10% body surface affected
• History of atopic dermatitis for at least 3 years (as per patient history)
• HEALTHY CONTROL COHORT
• At least 18 years of age

You may not qualify if…

• ATOPIC DERMATITIS COHORT
• Unstable or persistent asthma (mild, moderate, or severe), i.e. all forms of allergic asthma that are other than intermittent asthma. Intermittent asthma is allowed: Difficulty breathing, wheezing, chest tightness, and coughing occur on fewer than 2 days a week, do not interfere with normal activities, and nighttime symptoms occur on fewer than 2 days a month.
• Use of topical glucocorticosteroids or other immunosuppressive topical therapy within 1 week of treatment initiation. Emollients are allowed.
• Untreated skin malignancy
• Use of systemic anti-inflammatory medication in the last 4 weeks for more than 3 days
• Known photosensitivity: Hypersensitivity to sunlight or UVB light of any type or photosensitizing medication
• History of Lupus, Polymorphic light eruption (PMLE), or any disease known to be worsened by UV light exposure
• History of melanoma
• History, physical, social or lab findings suggestive of any medical or psychological condition that would, in the opinion of the PI make the candidate ineligible for the study
• HEALTHY CONTROL COHORT
• self-reported chronic inflammatory diseases (IBD, rheumatoid arthritis, collagenoses, chronic inflammatory skin disease, Atopic Dermatitis, autoimmune or autoinflammatory disease, active tuberculosis, chronic infectious disease such as HIV and hepatitis)

Where it is running

• The Rockefeller University — New York, New York, United States

Full record on ClinicalTrials.gov

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