Platelet Function on Abacavir and Tenofovir

Completed

Conditions studied: Cardiovascular Diseases, Platelet Aggregation, Spontaneous, HIV/AIDS

In brief

This is a small observational study aimed at observing differences in platelet function in HIV patients on abacavir versus tenofovir based anti-HIV drugs. There is some correlation between platelet activation and cardiovascular disease- this study will act as a pilot to see if platelet activation among abacavir users may explain the correlation between abacavir and cardiovascular disease in HIV positive patients. This study will enroll 44 participants total; 22 on abacavir-based treatment, 22 on tenofovir-based treatment. There is only one study visit which includes a blood draw, physical assessment, and review of medical history.

Key facts

Study ID

NCT03081572

Run by

University of California, Los Angeles

People needed

24

Starts

2018-04-30

Expected to finish

2020-02-15

Last updated by the study team

2020-11-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV positive
• Stable antiretroviral regimen for > 3months containing either abacavir or tenofovir
• Suppressed HIV viral load

You may not qualify if…

• Current cigarette smoking
• Pre-existing platelet disorder
• current or recent (last 6 months) antiplatelet therapy
• pregnancy

Where it is running

• Clinical AIDS Research and Education Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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