Probiotic on Psychological and Cognitive Effects

Completed · Not applicable · Has a placebo group

Conditions studied: Aging

In brief

This study will determine whether supplementation of probiotic Lactobacillus Rhamnosus GG improves psychological status in middle age and older adults through a 12-week, randomized, double-blind, placebo-controlled clinical trial. Secondary analyses will be conducted to examine the possible benefits of probiotic supplementation on cognitive function and markers of physical health.

Key facts

Study ID

NCT03080818

Run by

Kent State University

People needed

200

Starts

2017-02-01

Expected to finish

2019-07-01

Last updated by the study team

2020-02-20

Who can join

Age: 55 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 55-75 years
• Able to speak and read English

You may not qualify if…

• History of neurological, developmental, or severe psychiatric disorder (e.g. dementia, stroke, schizophrenia);
• Antibiotic use in the past 30 days;
• History of significant stomach or GI surgery (e.g. gastric bypass, cholecystectomy);
• History of alcohol or illicit drug dependence;
• History of severe heart, kidney, or liver problems (e.g. heart failure, liver failure);
• Regular use of an acid-blocking medication in the past 30 days (i.e. proton pump inhibitor, H2 blocker);
• Likely immunosuppression (e.g. chemotherapy treatment);
• Regular use of other pre- or probiotic supplements in the past 30 days;
• Severe gastrointestinal conditions including celiac disease, Crohn's disease, or diverticulitis.

Where it is running

• Kent State Uniersity — Kent, Ohio, United States

Full record on ClinicalTrials.gov

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