Microbiome and Sarcopenia in Patients With Liver Cirrhosis
Recruiting now · Not applicable
Conditions studied: Sarcopenia, Liver Cirrhosis
In brief
Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis. Severity of malnutrition correlates with progression of liver disease and leads to sarcopenia in 30-70% of cirrhotic patients. Malnutrition and sarcopenia are associated with an increased risk of complications and mortality. In cirrhosis the gut microbiome is altered leading to increased gut permeability, bacterial translocation and inflammation. Since the microbiome is involved in nutrient uptake and metabolism, it is hypothesized that microbiome alterations contribute to sarcopenia. A prospective controlled cohort study to investigate the interrelation of microbiome changes and sarcopenia in cirrhosis will be conducted. Furthermore the effect of nutritional interventions on the microbiome in cirrhosis will be studied. From this study information on how the gut microbiome composition and sarcopenia are associated in cirrhosis and if modulation of the gut microbiome by nutritional interventions is feasible will be collected.
Key facts
- Study ID
- NCT03080129
- Run by
- Medical University of Graz
- People needed
- 120
- Starts
- 2017-04-11
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2024-10-09
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Hospitalized patients for any reason with clinical/radiological/histological diagnosis of cirrhosis
- Age >18y
- Informed consent
- CT/MRI scan within +/-14 days of the baseline study visit
You may not qualify if…
- Hepatic encephalopathy > grade 2 and or other cognitive disorder not allowing informed consent
- advanced hepatocellular carcinoma
- Any other condition or circumstance, which, in the opinion of the investigator, would affect the patient's ability to participate in the protocol
Where it is running
- Medical University Graz — Graz, Austria (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.