Study of Aspirin in Patients With Vestibular Schwannoma

Running, not enrolling · Phase 2 · Has a placebo group

Conditions studied: Vestibular Schwannoma, Acoustic Neuroma, Neurofibromatosis 2

In brief

This is a phase II prospective, randomized, double-blind, longitudinal study evaluating whether the administration of aspirin can delay or slow tumor growth and maintain or improve hearing in VS patients.

Key facts

Study ID

NCT03079999

Run by

Massachusetts Eye and Ear Infirmary

People needed

97

Starts

2018-06-11

Expected to finish

2029-02-01

Last updated by the study team

2025-12-18

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Radiographic diagnosis of vestibular schwannoma (NF2-associated or sporadic).
• Age≥12 years.
• Ability to provide informed consent.Pediatric patients must provide assent in addition to their parents'/guardians' consent. Adult patients who cannot consent for themselves will not be eligible to participate in this study.
• Ability to swallow tablets.

You may not qualify if…

• Inability to perform volumetric measurements of vestibular schwannoma(s).
• Inability to tolerate MRI with contrast.
• Daily use of aspirin within the last two months. Occasional use of aspirin for pain relief is not exclusionary.
• Known allergy to aspirin.
• Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of aspirin.
• Pregnant or lactating women.
• Patients with serious medical illnesses (e.g. severe asthma) that in the option of the investigator could prevent participation in the trial.
• Active bleeding diathesis.
• Hydrocephalus from brainstem compression.
• Febrile illness or flu-like illness in children and adolescents less than 18 years of age.

Where it is running

• Stanford Otolaryngology/HNS — Stanford, California, United States
• University of Miami — Miami, Florida, United States
• Massachusetts Eye and Ear — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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