Flicker Fusion Thresholds Between Young and Old Subjects at Various Luminance Levels

Completed

Conditions studied: Age Factor, Age-related Macular Degeneration

In brief

The objective of this study is to determine which luminance levels yield maximum differences in critical flicker fusion (CFF) scores between younger and older normal subjects.

Key facts

Study ID

NCT03079570

Run by

ORA, Inc.

People needed

9

Starts

2016-08-23

Expected to finish

2016-09-08

Last updated by the study team

2017-03-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Provide written and informed consent;
• Be willing and able to follow all instructions and attend the study visit;
• Must be able to successfully complete all study procedures;
• If female and of childbearing potential, not be pregnant, nursing, or planning a pregnancy and be willing to submit a pregnancy test at Visit 1 (and exit visit as applicable) and utilize an acceptable form of birth control for the duration of the study;
• Be 18 years of age or older
• Have best-corrected distance visual acuity (BCVA) of better or equal to 20/30 in at least one eye at Visit 1;
• Have best-corrected near visual acuity of better or equal to 20/30 in at least one eye at Visit 1;
• Have visited an ophthalmologist for an eye exam within 1 year of Visit 1;

You may not qualify if…

• Have a history of age-related macular degeneration (exudative and non-exudative), diabetic retinopathy, retinal detachment, or any chronic retinopathy or retinal degenerative disease;
• Have had prior retinal vein or artery occlusion, history of macular edema, or optic neuropathy;
• Have a history of glaucoma or ocular hypertension
• Have visually significant cataracts at Visit 1;
• Have a history of ocular trauma;
• Have a history of photophobia reported at Visit 1;
• Report ocular discomfort of 2 or greater in either eye at Visit 1, or report any other ocular symptomatology that could in the opinion of the investigator interfere with study procedures;
• Have active signs or symptoms of conjunctivitis, uveitis, in either eye at the baseline examination of Visit 1;
• Be currently enrolled in an investigational drug or device study or have used an investigational drug or device within 7 days of entry into this study;
• Have used contact lenses 24 hours prior to the start of the study or be unwilling to discontinue wearing for the duration of the study;
• Have a history of uncontrolled systemic disease (e.g. poorly controlled hypertension or poorly controlled diabetes, a history of status asthmaticus, organ transplant) at Visit 1;
• Have a history of seizures;
• Be currently taking procyclidine, alprazolam (Xanax), lorazepam (Ativan), Adderall, or any psychotropic medications;
• Be a woman who is pregnant or nursing an infant
• Have a condition or be in a situation that the investigator feels may put the subject at significant risk, confound the study results, or interfere significantly with the subject's participation in the study;

Where it is running

• Andover Eye Associates — Andover, Massachusetts, United States

Full record on ClinicalTrials.gov

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