The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

Completed

Conditions studied: Sudden Cardiac Death

In brief

Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient population.

Key facts

Study ID

NCT03079414

Run by

Western University, Canada

People needed

100

Starts

2017-05-01

Expected to finish

2025-06-01

Last updated by the study team

2025-06-15

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unexplained cardiac arrest requiring cardioversion or defibrillation
• Willing and able to sign informed consent

You may not qualify if…

• Coronary artery disease (stenosis > 50%) and clinical findings consistent with an ischemic arrest
• Reduced left ventricular function (left ventricular ejection fraction < 50%) on echocardiogram or cardiac MRI.
• Persistent resting QTc > 460 msec for males and 480 msec for females
• Resting QTc < 350 msec
• Type I Brugada ECG with >/= 2 mm ST elevation in V1 and/or V2 (Spontaneous or Drug-Induced)
• Polymorphic or bidirectional ventricular tachycardia observed with exertion on exercise treadmill testing
• Clinical, electrocardiographic, and/or imaging findings consistent with a diagnosis of arrhythmogenic right ventricular cardiomyopathy
• Myocarditis
• Reversible cause of cardiac arrest such as marked hypokalemia (<2.8 mmol/l) or drug overdose sufficient in severity without other cause to explain the cardiac arrest.
• Arrhythmic mitral valve prolapse syndrome
• Documented ventricular fibrillation initiated by a short-coupled premature ventricular contraction

Where it is running

• UCLA Medical Center — Los Angeles, California, United States
• UC San Diego Health System — San Diego, California, United States
• UCSF Medical Center — San Francisco, California, United States
• Stanford University — Stanford, California, United States
• Queen's Medical Center — Honolulu, Hawaii, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Regions Hospital — Saint Paul, Minnesota, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Utah — Salt Lake City, Utah, United States
• Inova Heart and Vascular Institute — Falls Church, Virginia, United States
• University of Calgary — Calgary, Alberta, Canada
• British Columbia Children's Hospital — Vancouver, British Columbia, Canada
• University of British Columbia — Vancouver, British Columbia, Canada
• QEII Health Sciences Centre — Halifax, Nova Scotia, Canada
• Hamilton Health Sciences — Hamilton, Ontario, Canada
• London Health Sciences Centre — London, Ontario, Canada
• Toronto General Hospital — Toronto, Ontario, Canada
• Montreal Heart Institute — Montreal, Quebec, Canada
• Laval University — Québec, Quebec, Canada
• Tel-Aviv Sourasky Medical Center — Tel Aviv, Israel

Full record on ClinicalTrials.gov

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