The Relation of GnRH Treatment to QTc Interval in Transgender Females
Stopped early
Conditions studied: Gender Dysphoria
In brief
Background: The QT interval of the electrocardiogram (ECG), corrected for heart rate (QTc), is a measure of the duration of ventricular repolarization and is a widely used marker of ventricular arrhythmia risk. Testosterone has a shortening effect on QTc length, and the QTc interval in males is shorter than in females after the onset of puberty. Transgender female adolescents are treated with GnRH agonists or spironolactone that suppress endogenous testosterone secretion and might increase the QT interval sufficiently to increase the risk for malignant ventricular arrhythmias. There are no current guidelines regarding monitoring QTc interval in transgender females undergoing GnRH agonist treatment. Objective: To assess the effect of GnRH agonist treatment on QTc interval in transfemale youth. Methods: A quasi-experimental time series study of transgender female adolescent, seen at UCSF Child and Adolescent Gender Center (CAGC) during 2017-2019. Specific aims: To assess the impact of GnRH agonist treatment on QTc interval length in transgender female adolescent
Key facts
- Study ID
- NCT03078829
- Run by
- University of California, San Francisco
- People needed
- 3
- Starts
- 2017-05-01
- Expected to finish
- 2017-08-21
- Last updated by the study team
- 2018-12-26
Who can join
Age: 10 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Transgender males to females in pubertal stage Tanner stage 4-5
- starting GnRH agonist treatment
You may not qualify if…
- Heart disease or arrhythmias at base line
- Electrolyte abnormalities at baseline (abnormal serum levels of calcium, potassium or magnesium)
- Failure to obtain informed consent from a parent or guarding or informed assent from a youth.
Where it is running
- University of California, San Francisco — San Francisco, California, United States
Full record on ClinicalTrials.gov
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