Rare Diseases Clinical Research Network: Neurophysiological Correlates
Completed
Conditions studied: Rett Syndrome, Preserved Speech Variant, Mecp2 Duplication Syndrome, Rett-related Disorders
In brief
The overall purpose of this project is to advance understanding of the neurophysiological features of Rett syndrome (RTT), MECP2 Duplication (MECP2 Dup) and RTT-related disorders (CDKL5, FOXG1) to gain insight into disease pathogenesis, with an emphasis on identifying biomarkers of disease evolution and severity. This specific study is intertwined to the core study Natural History of Rett Syndrome and Related Disorders (RTT5211), which characterizes range of clinical involvement and genotype-phenotype correlations and will provide phenotypical data for determining the clinical relevance of the neurophysiologic parameters; study subjects here are co- and primarily enrolled in RTT5211. The proposed studies will serve as basis of future translational investigations, including further refinement of biomarkers, development of outcome measures, and clinical trials per se.
Key facts
- Study ID
- NCT03077308
- Run by
- University of Alabama at Birmingham
- People needed
- 185
- Starts
- 2017-01-02
- Expected to finish
- 2021-07-31
- Last updated by the study team
- 2021-08-05
Who can join
Age: 2 and older, up to 65. Sex: any. Healthy volunteers: accepted.
Where it is running
- University of Colorado Denver — Denver, Colorado, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- Cincinnati Children's Hospital — Cincinnati, Ohio, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Vanderbilt University — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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