A Study Evaluating MM-310 in Patients With Solid Tumors

Status unconfirmed · Phase 1

Conditions studied: Solid Tumors, Urothelial Carcinoma, Gastric Carcinoma, Squamous Cell Carcinoma of the Head and Neck, Ovarian Cancer, Pancreatic Ductal Adenocarcinoma, Prostate Adenocarcinoma, Non-small Cell Lung Cancer, Small Cell Lung Cancer, Triple Negative Breast Cancer, Endometrial Carcinoma, Soft Tissue Sarcoma

In brief

MM-310 is a liposomal formulation of a docetaxel prodrug that targets the EphA2 receptor on cancer cells. Docetaxel is an approved chemotherapeutic drug.This study is a Phase 1 open-label study of MM-310 in patients with solid tumors. In the first part of the study, MM-310 will be assessed as a monotherapy until a maximum tolerated dose (MTD) is established. After an MTD of MM-310 as a monotherapy is established, an expansion cohort and MM-310 in combination with other therapies will be assessed.

Key facts

Study ID

NCT03076372

Run by

Merrimack Pharmaceuticals

People needed

34

Starts

2017-02-22

Expected to finish

2018-12-01

Last updated by the study team

2018-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must have one of the following cancers, for which the patient has either received or been intolerant to all therapy known to confer clinical benefit
• Urothelial carcinoma
• Gastric/gastroesophageal junction/esophageal carcinoma (G/GEJ/E)
• Squamous Cell Carcinoma of the Head and neck (SCCHN)
• Ovarian cancer
• Pancreatic ductal adenocarcinoma (PDAC)
• Prostate adenocarcinoma (PAC)
• Non-small cell lung cancer (NSCLC)
• Small cell lung cancer (SCLC)
• Triple negative breast cancer (TNBC)
• Endometrial carcinoma
• Soft tissue sarcoma subtypes except GIST, desmoid tumors and pleomorphic rhabdomyosarcoma
• Able to provide informed consent, or have a legal representative able and willing to do so
• ≥ 18 years of age
• Availability of a cancerous lesion amenable to biopsy and willing to undergo a pre-treatment biopsy
• ECOG Performance Status of 0 or 1
• Adequate bone marrow reserve as evidenced by:
• ANC > 1,500/µl (unsupported by growth factors) and
• Platelet count > 100,000/µl
• Hemoglobin > 9 g/dL
• Patients must have adequate coagulation function as evidenced by prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) within normal institutional limits
• Adequate hepatic function as evidenced by:
• Serum total bilirubin ≤ ULN
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x ULN.
• Alkaline phosphatase ≤ 2.5 x ULN, unless the elevated alkaline phosphatase is due to bone metastasis.

You may not qualify if…

• Prior treatment with docetaxel within 6 months of study enrollment
• Pregnant or lactating
• Treatment with systemic anticoagulation (e.g. warfarin, heparin, low molecular weight heparin, anti-Xa inhibitors, etc.) except aspirin
• Any evidence of hematemesis, melena, hematochezia, ≥ grade 2 hemoptysis, or gross hematuria
• Any history of hereditary bleeding disorders
• Presence of an active infection or with an unexplained fever > 38.5°C during screening visits or on the first scheduled day of dosing, which in the investigator's opinion might compromise the patient's participation in the trial or affect the study outcome. At the discretion of the investigator, patients with tumor fever may be enrolled
• Known CNS metastases
• Known hypersensitivity to the components of MM-310, or docetaxel
• Prior treatment with MM-310
• Received treatment, within 28 days or 5 half-lives, whichever is shorter, prior to the first scheduled day of dosing, with any investigational agents that have not received regulatory approval for any indication or disease state and all prior clinically significant treatment related toxicities have resolved to Grade 1 or baseline
• Received other recent antitumor therapy including any standard chemotherapy or radiation within 14 days (or have not yet recovered from any actual toxicities of the most recent therapy) prior to the first scheduled dose of MM-310
• Received any anti-cancer drug known to have anti-VEGF/VEGFR activity within a period of 5 half-lives of this drug (e.g. 100 days for bevacizumab, 75 days for ramucirumab) prior to the first scheduled dose of MM-310
• Clinically significant cardiac disease, including: NYHA Class III or IV congestive heart failure, unstable angina, acute myocardial infarction within six months of planned first dose, arrhythmia requiring therapy (including torsades de pointes, with the exception of extrasystoles, minor conduction abnormalities, or controlled and well treated chronic atrial fibrillation)
• Patients who are not appropriate candidates for participation in this clinical study for any other reason as deemed by the investigator
• Patients who received organ or allogeneic bone marrow or peripheral blood stem cell transplants
• Chronic use of corticosteroids more than 10mg daily prednisone equivalent during the past 4 weeks prior to planned start of MM-310
• Concomitant use of strong inhibitors of CYP3A
• Patients with peripheral neuropathy of grade 2 or higher

Where it is running

• Honor Health — Scottsdale, Arizona, United States (enrolling)
• University California San Francisco — San Francisco, California, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Roswell Park Cancer Institute — Buffalo, New York, United States (enrolling)
• Duke University — Durham, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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