Longitudinal Assessment of Spinal Cord Structural Plasticity Using DTI in SCI Patients

Completed

Conditions studied: Spinal Cord Injuries

In brief

This study will apply novel magnetic resonance imaging (MRI) techniques to investigation of spinal cord injury (SCI) to learn how nerve fibers repair and neural cells regain ability to control muscle during the rehabilitation. The information gained will be helpful for physicians to make more accurate diagnosis of SCI, predict injury recovery and movement restoration, and develop more effective treatment plans.

Key facts

Study ID

NCT03069222

Run by

Kessler Foundation

People needed

19

Starts

2016-04-01

Expected to finish

2020-03-31

Last updated by the study team

2020-09-11

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• SCI due to single event traumatic injury; C4-T12 neurological level of injury, AIS grade B,C or D;
• currently medically stable;
• no history of seizure;
• spasticity at a score of 2 or lower assessed using Modified Ashworth Assessment of the upper and lower extremities;
• able to give informed consent;
• to stay still in the MR scanner for \~30 min.

You may not qualify if…

• MRI contraindications;
• younger than 18 and older than 75 years (this age range will limit contributions from nervous system development and aging to results of the study);
• history of epilepsy and other neurological diseases and trauma;
• drug and alcohol abuse;
• multi injury levels;
• severe craniocerebral injury and
• presence of non-MRI-safe post-operative hardware in the spine or brain.

Where it is running

• Kessler Foundation — West Orange, New Jersey, United States

Full record on ClinicalTrials.gov

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