Thrombosis Outcomes in Pediatric Venous Thromboembolism

Completed

Conditions studied: Venous Thromboembolism

In brief

'The TOP Study' is a prospective cohort study whose main objective is to develop better prognostic biomarkers and identify children at risk of adverse thrombotic outcomes very early in the course after an initial venous thromboembolic events (VTE). The study will compare biomarkers in children that develop poor VTE outcomes (such as recurrence, postthrombotic syndrome and post PE impairment ) after an initial VTE with those that do not develop such outcomes.

Key facts

Study ID

NCT03068923

Run by

University of Texas Southwestern Medical Center

People needed

120

Starts

2016-05-01

Expected to finish

2022-03-09

Last updated by the study team

2025-01-31

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Boys and girls age birth (0 years) to equal to or less than 21 years
• A radiologically confirmed first venous thromboembolism episode (both extremity and non-extremity) who have completed anticoagulation therapy as per the 9th edition of the ACCP guidelines

You may not qualify if…

• Known malignancy
• Pregnancy or immediate post-partum period (12 weeks after delivery)
• Sickle cell disease
• Known bleeding disorder

Where it is running

• Children's Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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