The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition
Running, not enrolling · Phase 2
Conditions studied: Cognitive Impairment, Carotid Artery Plaque, Inflammation
In brief
The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain inflammation, and (3) cognitive benefit from surgery. This project will uncover links between inflamed carotid plaque and downstream brain inflammation. The invesigators will also determine carotid plaque imaging features predicting cognitive benefit from carotid surgery.
Key facts
- Study ID
- NCT03068442
- Run by
- Scott Mcnally
- People needed
- 45
- Starts
- 2017-02-17
- Expected to finish
- 2030-09-10
- Last updated by the study team
- 2026-05-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients ≥18 years old and plans for carotid endarterectomy.
You may not qualify if…
- Patients with carotid occlusion will be excluded, due to one carotid contributing to both right and left brain blood supply.
- Other known sources of cardioembolism, including atrial fibrillation, mechanical heart valve, left atrial or ventricular thrombus or intracardiac mass, endocarditis, EF <30%
- Known stroke mimics including multiple sclerosis or brain tumor
- MRI contraindications per ACR guidelines, including patients with pacemakers, renal failure with eGFR<30 ml/min/1.73m2, and contrast allergy
- [18F]Flutemetamol contraindications per manufacturer guidelines, including patients with prior reactions
- Known stage IV malignancy
- Pregnancy
Where it is running
- University of Utah — Salt Lake City, Utah, United States
- George E. Wahlen Department of Veterans Affairs Medical Center — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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