Effects of Carbon Monoxide Breathing on Blood Vessel Function

Completed · Phase 1

Conditions studied: Endothelial Dysfunction

In brief

In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah smoking, augments endothelial function, thus implicating CO as the major endothelial vasodilator substance in hookah smoke. Rationale: Our group has demonstrated (PRO36547) that in contrast to cigarette smoking, hookah smoking (tobacco heated with charcoal) acutely augments, rather than impairs, brachial artery FMD. Importantly, our data strongly implicate-but do not prove-that the augmentation in FMD is caused by CO. Therefore; the investigators would like to extend the scientific priority of this work by directly investigating cause and effect of CO breathing (similar levels than ones obtained after hookah smoking) on brachial artery FMD.

Key facts

Study ID

NCT03067701

Run by

Cedars-Sinai Medical Center

People needed

9

Starts

2017-06-23

Expected to finish

2019-03-01

Last updated by the study team

2019-04-01

Who can join

Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-39 years of age

You may not qualify if…

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
• BP > 140/90 mmHg
• BMI <18.5 or > 30 kg·m2
• Resting heart rate > 100 beats/min
• Taking prescription medication
• Hemoglobin levels < 11.6 g/dL
• Total cholesterol > 240 or HDL < 36
• Fasting glucose >100 mg/dL or <60 mg/dL
• Bilirubin >1.2 mg/dL; albumin < 3.5 or > 5.5 g/dL; alkaline phosphatase (alk phos) >125 IU/L; alanine aminotransferase (ALT) > 45 U/L; aspartate aminotransferase (AST) > 35 U/L
• Positive (+) toxicology screen
• Pregnant

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.