Genetic Study of Familial Acute Lymphoblastic Leukemia
Completed
Conditions studied: Acute Lymphoblastic Leukemia (ALL)
In brief
Familial aggregation is well recognized in some cancers. Though a number of familial cancer predisposition syndromes have been described, the nature of inherited genetic alterations in patients with a strong history of familial cancer is currently unknown, as is the case with childhood acute lymphoblastic leukemia (ALL). The investigators are seeking to learn more about what causes leukemia and why some people and families may be at a higher risk of developing this disease. By understanding the origin of the disease, better treatments may be identified for patients with leukemia. PRIMARY OBJECTIVE: To identify variants in genes that are inherited, have altered gene structure and/or function, and influence the risk of developing acute lymphoblastic leukemia (ALL) and other cancers. SECONDARY OBJECTIVE: To collect demographic, clinical and laboratory information including detailed family cancer history and response of cancers to therapy for correlation with the primary objective.
Key facts
- Study ID
- NCT03067584
- Run by
- St. Jude Children's Research Hospital
- People needed
- 4
- Starts
- 2017-05-09
- Expected to finish
- 2017-06-23
- Last updated by the study team
- 2019-12-11
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient with acute lymphoblastic leukemia (ALL) and has a relative also diagnosed with ALL. Note: There is no upper age limit, and the index ALL case does not have to be a patient diagnosed and/or treated at St. Jude.
- Family members of the patient, either affected or unaffected by a malignancy, who are contacted by the patient (or guardian) and agree to participate in the study. Relatives may have been diagnosed with other malignant, genetic or developmental disorders.
- Research participant or legal guardian, as appropriate, must provide informed consent for this protocol.
Where it is running
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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