Long Term Follow Up for CTSN Mitral Valve Repair Studies

Running, not enrolling

Conditions studied: Mitral Valve Insufficiency, Coronary Artery Disease

In brief

This study is a continuation of two previous studies --- the Severe Ischemic Mitral Regurgitation (SMR) Trial (NCT00807040) and the Moderate Ischemic Mitral regurgitation (MMR) Trial (NCT00806988) --- to learn more about patients' health 5-10 years after their mitral valve surgeries. The investigators will collect long-term health information on SMR and MMR trial participants using electronic medical records, patient and/or family input, public records, and healthcare- and vital status-related databases.

Key facts

Study ID

NCT03066050

Run by

Icahn School of Medicine at Mount Sinai

People needed

368

Starts

2017-05-03

Expected to finish

2027-07-31

Last updated by the study team

2025-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Randomized patients in the MMR and SMR trials who were still alive at 2 years after the index cardiac surgical intervention

You may not qualify if…

• Patients participating in the MMR and SMR trials who withdrew consent prior to the 2-year follow-up evaluation

Where it is running

• University of Southern California — Los Angeles, California, United States
• Emory University — Atlanta, Georgia, United States
• University of Maryland — Baltimore, Maryland, United States
• Suburban Hospital — Bethesda, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Columbia University Medical Center — New York, New York, United States
• Montefiore Einstein Heart Center — The Bronx, New York, United States
• Mission Hospital — Asheville, North Carolina, United States
• Duke University — Durham, North Carolina, United States
• East Carolina Heart Institute — Greenville, North Carolina, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Baylor Research Institute — Plano, Texas, United States
• University of Virginia Health Systems — Charlottesville, Virginia, United States
• Inova Heart and Vascular Institute — Falls Church, Virginia, United States
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Sunnybrook Health Science Centre — Toronto, Ontario, Canada
• Saint Michael's Hospital — Toronto, Ontario, Canada
• Toronto General Hospital — Toronto, Ontario, Canada
• Montreal Heart Institute — Montreal, Quebec, Canada
• Centre Hospitalier de l'Université de Montréal — Montreal, Quebec, Canada
• Hôpital du Sacré-Cœur de Montréal — Montreal, Quebec, Canada
• Institut Universitaire de Cardiologie de Quebec (Hopital Laval) — Québec, Canada

Full record on ClinicalTrials.gov

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