Timing of Low Vision Rehabilitation in Anti- Vascular Endothelial Growth Factor (VEGF) Therapy

Completed · Not applicable

Conditions studied: Low Vision, Neovascular Age-related Macular Degeneration

In brief

The purpose of this research is to collect preliminary data in preparation for conducting a randomized clinical trial to determine the relative effectiveness of vision rehabilitation in improving overall visual ability (primary aim) and reducing depression (secondary aim) in patients receiving anti-VEGF therapy for neovascular age-related macular degeneration integrated over time.

Key facts

Study ID

NCT03065907

Run by

Johns Hopkins University

People needed

3

Starts

2018-01-15

Expected to finish

2019-12-01

Last updated by the study team

2019-12-16

Who can join

Age: 50 and older, up to 105. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 50 years old
• Primary diagnosis of neovascular age-related macular degeneration in the index eye or in both eyes if habitual visual acuity (HVA) is equivalent in both eyes
• HVA < 20/25 to ≥ 20/500 in the index eye
• Confirmed active anti-VEGF injections (a minimum of 2 injections in the past 3 months, a total of 8 injections maximum) in the index eye
• Full confrontational visual fields in the index eye
• Acknowledgement of having difficulty in visual ability function
• Visual ability estimates as measured by ≥ 2 goals identified on the Activity Inventory as important and with at least slight difficulty
• Telephone interview for cognitive status raw score is > 29
• Ability to return to clinic to participate in rehabilitation
• No prior experience with vision rehabilitation service

You may not qualify if…

• Other progressive ocular conditions likely to compromise VA during the study period or upcoming eye surgeries
• Anti-VEGF injections in the index eye 8 months prior to enrollment
• Unable to give written consent to the study
• Impaired hearing or cognitive ability that precludes telephone interviews
• Insufficient spoken English or reading ability to complete interviews and understand study materials
• The index eye is defined as the eye with better HVA, or the eye with more anti-VEGF injections if both eyes are with the equivalent HVA

Where it is running

• Wilmer Eye Institute — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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