ECPR for Refractory Out-Of-Hospital Cardiac Arrest
Completed · Not applicable
Conditions studied: Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, CPR, Extracorporeal Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation
In brief
In the U.S. alone, over 300,000 people per year have sudden out-of-hospital cardiac arrest (OHCA), and less than 1 out of 10 survive. The current standard practice for treating OHCA is to perform cardiopulmonary resuscitation (CPR) and Advanced Cardiovascular Life Support (ACLS) at the scene until either the heart is restarted or resuscitation efforts are considered hopeless and discontinued. An alternative strategy for those with refractory OHCA is expedited transport with ongoing mechanical CPR to an Emergency Department capable of performing extracorporeal cardiopulmonary resuscitation (ECPR). The purpose of study is to test if this strategy is feasible and beneficial.
Key facts
- Study ID
- NCT03065647
- Run by
- University of Michigan
- People needed
- 15
- Starts
- 2017-05-01
- Expected to finish
- 2020-03-05
- Last updated by the study team
- 2021-06-03
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- OHCA of presumed non-traumatic etiology requiring CPR
- Predicted arrival time at ECPR-capable hospital within timeframe specified
- Witnessed arrest or initial shockable rhythm (VT or VF)
- Persistent cardiac arrest after initial cardiac rhythm analysis and shock (if shock is indicated)
You may not qualify if…
- Sustained return of spontaneous circulation (ROSC)
- Advanced directive indicating do not attempt resuscitation (DNAR) or do not intubate (DNI)
- Preexisting evidence of opting out of study
- Prisoner
- Pregnant (obvious or known)
- ECPR capable ED is not at the destination hospital as determined by EMS
- Legally authorized representative (LAR) or family member aware of study and refuses study participation at the scene
Where it is running
- University of Michigan Hospital — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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