The Acute Effect of Spices on Vascular Health
Completed · Not applicable
Conditions studied: Oxidative Stress
In brief
The investigators aim to conduct a 3-period randomized controlled crossover study to investigate the postprandial effects of a high fat meal with spice on endothelial function, lipids/lipoproteins, immune function and plasma markers of antioxidants and oxidative stress. Metabolomic profiling will also be conducted. In random order, participants will consume either a high fat meal (1000kcal, 45g fat) or a high fat meal containing 2g of spice or a high fat meal containing 6g of spice. Between each treatment there will be a washout period of at least 3 days. It is hypothesized that consumption of a high fat meal with spice will attenuate postprandial endothelial impairment and triglyceride levels in a dose response manner compared with a high fat meal.
Key facts
- Study ID
- NCT03064958
- Run by
- Penn State University
- People needed
- 13
- Starts
- 2016-09-13
- Expected to finish
- 2018-03-29
- Last updated by the study team
- 2023-08-21
Who can join
Age: 40 and older, up to 65. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- male aged 40-65 years
- BMI 25-35kg/m2
- nonsmoking
- waist circumference =/> 94cm and at least one other CVD risk factor (elevated LDL-C (> 130 mg/dL), CRP (> 1 mg/L), elevated Triglycerides (≥ 150 mg/dL), reduced HDL-cholesterol (< 40 mg/dL), elevated blood pressure (systolic BP ≥ 130 or diastolic BP ≥ 85 mm Hg), elevated fasting glucose (≥ 100 mg/dL))
- low herb/spice consumers (consumption <1/day)
You may not qualify if…
- Chronic disease risk factors that are diagnostic of diabetes (fasting glucose > 126 mg/dL) or hypertension (SBP >160 mm Hg or DBP > 100 mm Hg).
- Prescription of anti-hypertensive or glucose lowering drugs.
- Established CVD, stroke, diabetes, liver, kidney or autoimmune disease
- Use of cholesterol/lipid-lowering medication or supplements (psyllium, fish oil, soy lecithin, and phytoestrogens) and botanicals
- weight loss of ≥10% of body weight within the 6 months prior to enrolling in the study
- vegetarianism
Where it is running
- Penn State University — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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