Neurodegeneration in Newborns After Anesthetics

Completed

Conditions studied: Neurodegeneration, General Anesthesia

In brief

The purpose of the study is to quantify biomarkers of neural damage in neonates exposed to varying levels of volatile anesthetic in utero.

Key facts

Study ID

NCT03064607

Run by

University of Pennsylvania

People needed

25

Starts

2010-11-05

Expected to finish

2018-02-06

Last updated by the study team

2019-02-19

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women delivering a child via cesarean section or EXIT procedure
• Informed consent

You may not qualify if…

• Known fetal neurologic defect
• Known maternal neurologic abnormality
• Sensitivity or allergy to medications used in the study
• C-section under epidural anesthesia: induction and maintenance with 1.5% lidocaine, sodium bicarbonate and 1:200,000 epinephrine
• C-section under general anesthesia: induction with propofol 2 mg/kg and succinylcholine 2 mg/kg intravenously; maintenance with desflurane 4.5-5%
• EXIT procedure under general anesthesia: induction with propofol 2 mg/kg and succinylcholine 2 mg/kg intravenously; maintenance with desflurane 15-18%

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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