Mechanisms of Weight Loss in Patients Diagnosed With Achalasia

Completed

Conditions studied: Achalasia

In brief

Currently there are no existing data to determine why some achalasia patients lose weight while others do not. The purpose of this study is to gather data from patients diagnosed with achalasia to determine if differences may be identified between those who lose weight and those who do not that would help us better understand the mechanism of weight loss in this population.

Key facts

Study ID

NCT03063463

Run by

Vanderbilt University Medical Center

People needed

7

Starts

2017-02-15

Expected to finish

2023-09-12

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is able to provide written informed consent to participate in the study before completing any study-related procedures
• Subject is male or female aged 18-75 years, inclusive at time of consent.
• Subject has a documented diagnosis of achalasia based on high resolution manometry and endoscopy report.
• Subject has been or will be scheduled to undergo either EGD with pneumatic dilation or surgical myotomy as routine care for treatment of achalasia.
• Subject is willing and has an understanding and ability to fully comply with study procedures and restrictions defined in this protocol.

You may not qualify if…

• Subject has any condition or abnormality, current or past that, in the opinion of the principal investigator, would compromise the safety of the subject or interfere with or complicate the assessment of signs or symptoms of achalasia. Such conditions may include psychiatric problems; neurologic deficits or disease; developmental delay; lung transplant; or previous gastroesophageal surgery.
• Subject has had previous pneumatic dilation of treatment of achalasia.
• Subject has had botulinum toxin (botox) injection for treatment of achalasia.
• Subject has a history or high risk of noncompliance with treatment or regular clinic visits.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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