The Effect of Spice Consumption on Postprandial Vascular Function
Completed · Not applicable
Conditions studied: Cardiovascular Risk Factor
In brief
A 3-period randomized cross-over, controlled feeding study will be conducted to determine the effect of chronic spice consumption on postprandial vascular function. Participants will consume three test diets containing different amounts of spice. Each treatment period will last for 4 weeks. After each diet period a meal test will be conducted. Participants will consume a meal with a spice content corresponding to the diet period they have just completed. Endothelial function will be measured at 2 and 4 hours after meal consumption. Blood samples will also be taken during the 4 hours after meal consumption for measurement of lipids, immune and inflammatory markers.
Key facts
- Study ID
- NCT03063320
- Run by
- Penn State University
- People needed
- 43
- Starts
- 2017-01-25
- Expected to finish
- 2020-02-26
- Last updated by the study team
- 2023-09-18
Who can join
Age: 30 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and postmenopausal women Overweight or obese (25-35kg/m2) Non-smoking Waist circumference >= 94cm for men and >=80cm for women
- At least one other of the following:
- LDL- cholesterol >130mg/dL
- CRP >1mg/L
- Triglycerides >=150mg/dL
- HDL <40mg/dL for men or <50mg/dL for women
- Systolic blood pressure >= 130mmHg or diastolic >= 85mmHg
- Fasting glucose >=100mg/dL
You may not qualify if…
- Diabetes (fasting glucose >126mg/dL)
- Hypertension (systolic blood pressure >160mmHg or diastolic blood pressure >100mmHg)
- Prescribed anti-hypertensive or glucose lowering drugs
- Established cardiovascular disease, stroke, diabetes, liver, kidney or autoimmune disease
- Use of cholesterol/lipid lowering medication or supplementation (psyllium, fish oil, soy lecithin, phytoestrogens) and botanicals
- Pregnancy or lactation
- Weight loss of >=10% of body weight within the 6 months prior to enrolling in the study
- Vegetarianism
Where it is running
- Penn State University — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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