Remediation of the Non-Paretic Arm in Stroke

Completed · Not applicable · Has a placebo group

Conditions studied: Stroke

In brief

Stroke survivors with severe contralesional paresis often have substantial control and coordination deficits in the non-paretic arm. Because this arm must serve as the primary controller, these deficits can be functionally devastating. The investigators now hypothesize that the combination of severe paresis (Upper Extremity Fugl-Meyer Score ≤35) and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. The investigators predict that remediation, focused on the non-paretic arm should improve functional independence. The investigators propose a randomized study design with two tracts, two periods and four assessments. The investigators envision this study as the first step in establishing the basis for a rehabilitation approach that focuses on remediation of BOTH arms, which constitutes a substantial change from current remediation protocols focused only on the contralesional arm.

Key facts

Study ID

NCT03062930

Run by

Milton S. Hershey Medical Center

People needed

15

Starts

2016-08-20

Expected to finish

2018-12-01

Last updated by the study team

2019-03-28

Who can join

Age: 21 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects will be between 21 and 85 years old of either gender
• Subjects will demonstrate cognitive abilities required to follow commands and engage in the experimental task
• Subjects will have had a unilateral stroke at least 3 months prior to participation resulting in upper extremity motor deficits

You may not qualify if…

• hospitalization for substance abuse and/or a major psychiatric diagnosis (schizophrenia);
• non-stroke neurological diseases that may affect ability to perform task or upper limb motor function
• certain peripheral movement restrictions, such as neuropathy
• neuroradiological confirmation of concomitant damage to the cerebellum or brain stem or extensive periventricular white matter changes (based on consultation with neuroradiology)

Where it is running

• Penn State College of Medicine; Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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