Laser Enucleation of Prostate (LEP) Versus Transurethral Resection of Prostate (TURP)

Stopped early · Not applicable

Conditions studied: Benign Prostatic Hyperplasia

In brief

Benign prostatic hyperplasia (BPH) refers to the proliferation of smooth muscle and epithelial cells of the prostate gland. The enlarged gland has the potential to result in lower urinary tract symptoms (LUTS) secondary to either bladder outlet obstruction or increased muscle tone and resistance, or both. For decades transurethral resection of the prostate (TURP) has been the gold standard for treatment of symptomatic BPH that is refractory to nonoperative management. This is a surgical intervention aimed to reduce the size of the prostate gland. However, over the past fifteen years, many alternative therapies have been introduced including laser enucleation of the prostate (LEP). LEP has numerous advantages including decreased blood loss and length of hospital stay as well as increased effectiveness and safety for large prostate gland sizes (\>80g).

Key facts

Study ID

NCT03062111

Run by

Boston University

People needed

3

Starts

2017-10-23

Expected to finish

2021-01-15

Last updated by the study team

2021-02-03

Who can join

Age: 50 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male
• Age > 50-80 years
• Prostate gland size 50-100g
• Failure of nonoperative therapy
• IPSS 8+
• FR <15ml/s
• PVR <250
• If PVR is 250-400 then pre-operative urodynamics will be indicated
• Language: English, Spanish, Haitian Creole, French, Portuguese
• Willing to randomize

You may not qualify if…

• Neurogenic bladder
• PVR >400ml
• IPSS <8
• FR >15ml/Indwelling catheter
• History of prostate cancer
• History of urethral stricture or vesicourethral anastomotic stricture
• Unable to be placed in lithotomy position
• Unable to undergo general or spinal anesthesia
• Unable to consent
• Untreated or uncorrected coagulopathy

Where it is running

• Boston University Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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